CRISPR/Cas9 gene editing boosts effectiveness of ultrasound cancer therapy
Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor. However, the treatment isn’t very effective because cancer cells can activate antioxidant defense systems to counteract it. Now, researchers have breached these defenses with CRISPR/Cas9 gene editing, allowing sonodynamic therapy to effectively shrink tumors in a mouse model of liver cancer.
Materials provided by American Chemical Society. Note: Content may be edited for style and length.
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