Colon cancer: How mutation of the APC gene disrupts lymphocyte migration
In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers describe the mechanisms that modify the structure of T lymphocytes and hinder their migration towards the tumors to be destroyed. This discovery provides new perspectives on the migration of immune cells, a key process in antitumor immune defense.
Materials provided by Institut Pasteur. Note: Content may be edited for style and length.
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