Breakthrough in study of how epithelial cells become cancerous
Researchers have shown that the oncogene-encoded molecule Src is responsible for epithelial cells developing invasive potential and overcoming the normal cellular defense of apical extrusion, but only when Src is located in lipid rafts in the cell membrane. Src is recruited and activated into lipid rafts by a molecule called CDCP1, which forms a molecular scaffold within the lipid rafts. CDCP1 could therefore be a promising new drug target for early-stage cancers.
Materials provided by Osaka University. Note: Content may be edited for style and length.
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