Scientists uncover novel DNA repair mechanism for key cancer target



Scientists uncover novel DNA repair mechanism for key cancer target

Scientists have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair. The work uncovers an unappreciated role for POLQ in responding to DNA replication stress, providing the scientific underpinnings for a Phase I clinical trial evaluating the effects of blocking this enzyme in cancer patients.

Materials provided by The Francis Crick Institute. Note: Content may be edited for style and length.




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