Light-induced acceleration of intracellular delivery
Researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions — due to the photothermal effect — by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).
Materials provided by Osaka Metropolitan University. Note: Content may be edited for style and length.
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