Researchers identify key source of T cell ‘exhaustion’
Scientists show the commanding role of a specialized group of proteins in the nuclei of our cells, called mSWI/SNF (or BAF) complexes, both in activating T cells to attack cancer and triggering exhaustion. The discovery suggests that targeting certain of these complexes, either by gene-cutting technologies such as CRISPR or with targeted drugs, could reduce T cell exhaustion and give CAR T cells (and in general, all tumor-fighting T cells) the staying power to take on cancer.
Materials provided by Dana-Farber Cancer Institute. Note: Content may be edited for style and length.
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